abstract：:Isolated floccular infarction is extremely rare, and impairments of the vestibulo-ocular reflex (VOR) have not been explored in humans with isolated floccular lesions. The purpose of this study was to examine and report selective impairment of VOR in response to high acceleration using head impulse in a patient with i...

journal_title：Journal of neurology

authors： Park HK,Kim JS,Strupp M,Zee DS

更新日期：2013-06-01 00:00:00

abstract：:Additional autoimmune diseases in people with multiple sclerosis (MS) and their relatives have been studied many times. Studies have employed different designs, and yielded conflicting results. We performed a systematic review, and calculated overall risk of additional autoimmune diseases in people with MS and their f...

journal_title：Journal of neurology

authors： Dobson R,Giovannoni G

更新日期：2013-05-01 00:00:00

abstract：:Recent studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign familial infantile seizures (BFIS). PRRT2 is a presynaptic protein which seems to play an importan...

journal_title：Journal of neurology

authors： Becker F,Schubert J,Striano P,Anttonen AK,Liukkonen E,Gaily E,Gerloff C,Müller S,Heußinger N,Kellinghaus C,Robbiano A,Polvi A,Zittel S,von Oertzen TJ,Rostasy K,Schöls L,Warner T,Münchau A,Lehesjoki AE,Zara F,Lerch

更新日期：2013-05-01 00:00:00

abstract：:A major challenge in the diagnosis of disorders of consciousness is the differential diagnosis between the vegetative state (VS) and the minimally conscious state (MCS). Clinically, VS is defined by complete unawareness, whereas MCS is defined by the presence of inconsistent but clearly discernible behavioural signs o...

journal_title：Journal of neurology

authors： Kotchoubey B,Merz S,Lang S,Markl A,Müller F,Yu T,Schwarzbauer C

更新日期：2013-04-01 00:00:00

abstract：:Spinocerebellar ataxias (SCA) are a genetically heterogeneous group of neurodegenerative diseases characterised by progressive cerebellar ataxia, dysarthria and oculomotor abnormalities. Recently the prodynorphin (PDYN) gene was identified as the cause of SCA23 in four Dutch families displaying progressive gait and li...

journal_title：Journal of neurology

authors： Fawcett K,Mehrabian M,Liu YT,Hamed S,Elahi E,Revesz T,Koutsis G,Herscheson J,Schottlaender L,Wardle M,Morrison PJ,Morris HR,Giunti P,Wood N,Houlden H

更新日期：2013-03-01 00:00:00

abstract：:Recent genetic studies suggest a Sardinian type of amyotrophic lateral sclerosis (ALS). Thus, ALS incidence, prevalence and survival were investigated in a large population of Sardinians aimed to disclose population-specific patterns and their temporal changes. This is a population-based incidence and prevalence study...

journal_title：Journal of neurology

authors： Pugliatti M,Parish LD,Cossu P,Leoni S,Ticca A,Saddi MV,Ortu E,Traccis S,Borghero G,Puddu R,Chiò A,Pirina P

更新日期：2013-02-01 00:00:00

abstract：:Non-motor symptoms (NMS) of Parkinson's disease (PD) have only recently been increasingly recognized for their impact on a patient's quality of life. In this study, we applied the validated, comprehensive self-completed NMS questionnaire for PD (NMS Quest) to 101 patients with young-onset PD (onset between 21 and 45 y...

journal_title：Journal of neurology

authors： Spica V,Pekmezović T,Svetel M,Kostić VS

更新日期：2013-01-01 00:00:00

abstract：:Little is known about the pattern of subacute cognitive domain impairments after ischaemic stroke, nor the temporal evolution of such impairments. Our objective was to investigate the pattern of cognitive impairment in different neuropsychological domains up to a year after ischaemic stroke. We included prospectively ...

journal_title：Journal of neurology

authors： Hurford R,Charidimou A,Fox Z,Cipolotti L,Werring DJ

更新日期：2013-01-01 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder of progressive heterotopic ossification (HO) caused by a recurrent activating mutation of ACVR1/ALK2, a bone morphogenetic protein (BMP) type I receptor. FOP is characterized by progressive HO, which is associated with inflammation in the setting o...

journal_title：Journal of neurology

authors： Kan L,Kitterman JA,Procissi D,Chakkalakal S,Peng CY,McGuire TL,Goldsby RE,Pignolo RJ,Shore EM,Kaplan FS,Kessler JA

更新日期：2012-12-01 00:00:00

abstract：:We explored how changes in visual attention impacted postural motor performance in healthy elders and adults post-stroke within a virtual reality environment, including when vestibular information was not perceptible. Visual dependence in 13 healthy (50-80 years) and 13 adults post-stroke (49-70 years) was assessed wi...

journal_title：Journal of neurology

authors： Slaboda JC,Keshner EA

更新日期：2012-12-01 00:00:00

abstract：:Cerebellar dysfunction is an important contributor to disability in patients with multiple sclerosis (MS), however, few in vivo studies focused on cerebellar volume loss so far. This relates to technical challenges regarding the segmentation of the cerebellum. In this study, we evaluated the semi-automatic ECCET softw...

journal_title：Journal of neurology

authors： Weier K,Beck A,Magon S,Amann M,Naegelin Y,Penner IK,Thürling M,Aurich V,Derfuss T,Radue EW,Stippich C,Kappos L,Timmann D,Sprenger T

更新日期：2012-12-01 00:00:00

abstract：:Mutations in C19orf12 have been recently identified as the molecular genetic cause of a subtype of neurodegeneration with brain iron accumulation (NBIA). Given the mitochondrial localization of the gene product the new NBIA subtype was designated mitochondrial membrane protein-associated neurodegeneration. Frequent fe...

journal_title：Journal of neurology

authors： Deschauer M,Gaul C,Behrmann C,Prokisch H,Zierz S,Haack TB

更新日期：2012-11-01 00:00:00

abstract：:The neuropsychiatric symptoms and behavioral disorders affecting Parkinson's disease (PD) patients are common and disabling. A PD-specific interview-based 12-item scale, the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's Disease (SEND-PD), has been developed to assess the severity of neuropsychiatri...

journal_title：Journal of neurology

authors： Martinez-Martin P,Frades-Payo B,Agüera-Ortiz L,Ayuga-Martinez A

更新日期：2012-11-01 00:00:00

abstract：:Decreased tongue strength (TS) might herald bulbar involvement in patients with amyotrophic lateral sclerosis (ALS) well before dysarthria or dysphagia occur, and as such might be prognostic of short survival. The purpose of this study was to investigate the prognostic value of a decreased TS, in addition to other pro...

journal_title：Journal of neurology

authors： Weikamp JG,Schelhaas HJ,Hendriks JC,de Swart BJ,Geurts AC

更新日期：2012-11-01 00:00:00

abstract：:Apraxia of lid opening (ALO) is a non-paralytic inability to open the eyes or sustain lid elevation at will. The exact pathophysiological mechanisms underlying the syndrome are still unknown. ALO has been reported in patients with Parkinson's disease (PD) after subthalamic nucleus (STN) deep brain stimulation (DBS), s...

journal_title：Journal of neurology

authors： Tommasi G,Krack P,Fraix V,Pollak P

更新日期：2012-09-01 00:00:00

abstract：:Elevated uric acid levels have recently been found to be associated with slower disease progression in Parkinson's disease, Huntington's disease, multiple system atrophy, and mild cognitive impairment. The aim of this study is to determine whether serum uric acid levels predict survival in amyotrophic lateral sclerosi...

journal_title：Journal of neurology

authors： Paganoni S,Zhang M,Quiroz Zárate A,Jaffa M,Yu H,Cudkowicz ME,Wills AM

更新日期：2012-09-01 00:00:00

abstract：:The aim of this work was to determine whether survival changed during 2002-2009 at a French amyotrophic lateral sclerosis (ALS) center. We included all patients with ALS who were seen consecutively at the center from January 2002-May 2009. Participants were followed from date of first visit through death, date of cens...

journal_title：Journal of neurology

authors： Gordon PH,Salachas F,Bruneteau G,Pradat PF,Lacomblez L,Gonzalez-Bermejo J,Morelot-Panzini C,Similowski T,Elbaz A,Meininger V

更新日期：2012-09-01 00:00:00

abstract：:Little is known about the relationship between cognitive dysfunctions and the non-motor complex in subjects with newly diagnosed untreated Parkinson's disease (PD). The aim of this study was to explore the association between non-motor symptoms (NMS) and cognitive dysfunctions in an incident cohort of de novo, drug-na...

journal_title：Journal of neurology

authors： Erro R,Santangelo G,Picillo M,Vitale C,Amboni M,Longo K,Costagliola A,Pellecchia MT,Allocca R,De Rosa A,De Michele G,Santoro L,Barone P

更新日期：2012-09-01 00:00:00

abstract：:The purpose of this study was to evaluate the contribution of posterior circulation to memory function by comparing memory scores between patients with and without a foetal-type posterior cerebral artery (FTP) during the intracarotid amobarbital procedure (IAP) in epilepsy patients. Patients undergoing bilateral IAP b...

journal_title：Journal of neurology

authors： Zijlmans M,Huibers CJ,Huiskamp GJ,de Kort GA,Alpherts WC,Leijten FS,Hendrikse J

更新日期：2012-08-01 00:00:00

abstract：:REM sleep behavior disorder (RBD) is known to be observed more frequently in patients with an α-synucleinopathy such as Parkinson's disease (PD) than in the general population. The precise prevalence of RBD in Japanese PD patients is not known. Therefore, we investigated the prevalence and the clinical characteristics...

journal_title：Journal of neurology

authors： Nihei Y,Takahashi K,Koto A,Mihara B,Morita Y,Isozumi K,Ohta K,Muramatsu K,Gotoh J,Yamaguchi K,Tomita Y,Sato H,Seki M,Iwasawa S,Suzuki N

更新日期：2012-08-01 00:00:00

abstract：:The geste antagoniste is a voluntary maneuver that temporarily reduces the severity of dystonic posture or movements. It is a classical feature of focal and particularly cervical dystonia. However, the precise historical aspects of geste antagoniste still remain obscure. The goals of this review were (1) to clarify th...

journal_title：Journal of neurology

authors： Poisson A,Krack P,Thobois S,Loiraud C,Serra G,Vial C,Broussolle E

更新日期：2012-08-01 00:00:00

abstract：:Nerve conduction studies (NCS) and electromyography (EMG), often shortened to 'EMGs', are a useful adjunct to clinical examination of the peripheral nervous system and striated skeletal muscle. NCS provide an efficient and rapid method of quantifying nerve conduction velocity (CV) and the amplitude of both sensory ner...

journal_title：Journal of neurology

authors： Kane NM,Oware A

更新日期：2012-07-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (XALD), a neurological disorder caused by mutations in the peroxisomal membrane protein gene ABCD1, presents as a rapidly progressing, inflammatory cerebral demyelination (cerebral cases) or a slowly progressing, distal axonopathy (non-cerebral cases). Specific ABCD1 defects do not explai...

journal_title：Journal of neurology

authors： Brose RD,Avramopoulos D,Smith KD

更新日期：2012-07-01 00:00:00

abstract：:The recent discovery of disease specific and pathogenic autoantibodies in neuromyelitis optica (NMO, Devic's disease) has revived the interest in this intriguing yet often devastating condition. While the history of classic multiple sclerosis has been studied extensively, only very little is known so far about the ear...

journal_title：Journal of neurology

authors： Jarius S,Wildemann B

更新日期：2012-07-01 00:00:00

abstract：:Small retrospective case series suggest that decompressive hemicraniectomy can be life saving in patients with cerebral venous thrombosis (CVT) and impending brain herniation. Prospective studies of consecutive cases are lacking. Thus, a single centre, prospective study was performed. In 2006 we adapted our protocol f...

journal_title：Journal of neurology

authors： Zuurbier SM,Coutinho JM,Majoie CB,Coert BA,van den Munckhof P,Stam J

更新日期：2012-06-01 00:00:00

abstract：:Fabry disease (FD) is a rare inherited disorder of the metabolism, associated with renal, cardiac, and cerebrovascular complications. Ischemic and hemorrhagic stroke in FD present with a similar proportion to that observed in the general population, but usually at an early age. Ischemic stroke may result from cardiac ...

journal_title：Journal of neurology

authors： Viana-Baptista M

更新日期：2012-06-01 00:00:00

abstract：:Patients in a minimally conscious state (MCS) show restricted signs of awareness but are unable to communicate. We assessed cerebral glucose metabolism in MCS patients and tested the hypothesis that this entity can be subcategorized into MCS- (i.e., patients only showing nonreflex behavior such as visual pursuit, loca...

journal_title：Journal of neurology

authors： Bruno MA,Majerus S,Boly M,Vanhaudenhuyse A,Schnakers C,Gosseries O,Boveroux P,Kirsch M,Demertzi A,Bernard C,Hustinx R,Moonen G,Laureys S

更新日期：2012-06-01 00:00:00

abstract：:Despite ongoing improvements in the acute treatment of cerebrovascular diseases and organization of stroke services, many stroke survivors are in need of neurorehabilitation, as more than two-thirds show persisting neurologic deficits. While early elements of neurorehabilitation are already taking place on the stroke ...

journal_title：Journal of neurology

authors： Albert SJ,Kesselring J

更新日期：2012-05-01 00:00:00

abstract：:In Parkinson's disease (PD), nonmotor symptoms manifest before motor symptoms. In this report, we present a remarkable case of a semiprofessional painter with PD whose painting style dramatically changed from abstract painting to realism before he developed motor, psychiatric, and autonomic nerve disorders. This case ...

journal_title：Journal of neurology

authors： Shimura H,Tanaka R,Urabe T,Tanaka S,Hattori N

更新日期：2012-05-01 00:00:00

abstract：:The CHA(2)DS(2)-VASc score was developed to improve stroke risk stratification in atrial fibrillation (AF) patients. We sought to analyze the distribution and prognostic value of the CHA(2)DS(2)-VASc score in a cohort of ischemic stroke patients with AF. In total, 439 consecutive stroke patients with AF were studied. ...

journal_title：Journal of neurology

authors： Giralt-Steinhauer E,Cuadrado-Godia E,Ois Á,Jiménez-Conde J,Rodríguez-Campello A,Planellas L,Jimena-García S,Rubio MÁ,Roquer-González J

更新日期：2012-04-01 00:00:00

abstract：:The United Nations High Commissioner for Refugees (UNHCR) recognizes 43.7 million forcibly displaced persons and asylum seekers due to conflict and persecution worldwide. Neurological disorders have rarely been described in displaced persons but likely pose a significant burden of disease. We describe the disease spec...

journal_title：Journal of neurology

authors： Mateen FJ,Carone M,Nyce S,Ghosn J,Mutuerandu T,Al-Saedy H,Lowenstein DH,Burnham G

更新日期：2012-04-01 00:00:00

abstract：:The aims of this study are to investigate whether auditory dysfunction is part of the spectrum of neurological abnormalities associated with Leber's hereditary optic neuropathy (LHON) and to determine the perceptual consequences of auditory neuropathy (AN) in affected listeners. Forty-eight subjects confirmed by genet...

journal_title：Journal of neurology

authors： Rance G,Kearns LS,Tan J,Gravina A,Rosenfeld L,Henley L,Carew P,Graydon K,O'Hare F,Mackey DA

更新日期：2012-03-01 00:00:00

abstract：:Studies of the relationship between Alzheimer's disease (AD) and polymorphism in the promoter region of Interleukin 6 (IL-6) -174 G/C have reported inconsistent results. To assess the association between IL-6 -174 G/C promoter polymorphism and AD risk, a meta-analysis containing 3,101 AD cases and 3,860 controls from ...

journal_title：Journal of neurology

authors： Dai L,Liu D,Guo H,Wang Y,Bai Y

更新日期：2012-03-01 00:00:00

abstract：UNLABELLED:The aim of the study was to assess adjunctive intravenous dexamethasone in adult community-acquired bacterial meningitis (BM) in daily practice. Analysis of consecutive patients (1990-2009) with acute community-acquired bacterial meningitis in a single centre in Zagreb, Croatia, N = 304. Adjusted relative ri...

journal_title：Journal of neurology

authors： Peterković V,Trkulja V,Kutleša M,Krajinović V,Lepur D

更新日期：2012-02-01 00:00:00

abstract：:The association of pathology and neurological deficit with quality of life (QoL) in multiple sclerosis (MS) is not fully understood. In this study, magnetic resonance imaging (MRI) measures of pathology--T1 and T2 lesion volume and ratio; active T2 lesion number; global and regional brain volume and atrophy; magnetiza...

journal_title：Journal of neurology

authors： Hayton T,Furby J,Smith KJ,Altmann DR,Brenner R,Chataway J,Hunter K,Tozer DJ,Miller DH,Kapoor R

更新日期：2012-02-01 00:00:00

abstract：:Leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate (LBSL) is a rare, autosomal recessive disorder caused by mutations in the gene encoding a mitochondrial aspartyl-tRNA synthetase, DARS2. The disease is characterized by progressive spastic ataxia and magnetic resonance imaging (MRI) sh...

journal_title：Journal of neurology

authors： Tzoulis C,Tran GT,Gjerde IO,Aasly J,Neckelmann G,Rydland J,Varga V,Wadel-Andersen P,Bindoff LA

更新日期：2012-02-01 00:00:00

abstract：:Psychiatric complaints are common in Parkinson's disease (PD), and have a significant influence in disease outcome and quality of life. Little attention has been paid to psychiatric symptoms at early stage disease. We aimed to screen a population of early stage PD patients for psychiatric symptoms and to study the rel...

journal_title：Journal of neurology

authors： Bugalho P,da Silva JA,Cargaleiro I,Serra M,Neto B

更新日期：2012-01-01 00:00:00

abstract：:The diagnosis of neurosarcoidosis is often difficult; the imaging signs of spinal cord sarcoidosis sometimes mimic those of cervical spondylotic myelopathy, which is common in elderly persons. We examined the characteristics of spinal cord sarcoidosis in Japanese patients with neurosarcoidosis. This case series identi...

journal_title：Journal of neurology

authors： Sakushima K,Yabe I,Nakano F,Yoshida K,Tajima Y,Houzen H,Maruo Y,Sasaki H

更新日期：2011-12-01 00:00:00

abstract：:We report a case of polycythemia vera with chorea in which the brain metabolism and dopamine system were investigated using 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) and (99m)Tc-labeled tropane dopamine transporter ((99m)Tc-TRODAT-1) single photon emission computed tomography (SPECT). Al...

journal_title：Journal of neurology

authors： Huang HC,Wu YC,Shih LY,Lo WC,Tsai CH,Shyu WC

更新日期：2011-11-01 00:00:00

abstract：:Natalizumab (TYSABRI(®)), a specific α4-integrin antagonist, is approved as a second-line treatment of relapsing-remitting MS (RRMS) patients who fail therapy with interferons or as first-line treatment of patients with highly active relapsing-remitting disease. Since the market introduction of natalizumab as a monoth...

journal_title：Journal of neurology

authors： Hellwig K,Gold R

更新日期：2011-11-01 00:00:00